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. 2018 May 14;9:965. doi: 10.3389/fimmu.2018.00965

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Copyright © 2018 Yao, Huang, Li, Li, Qian, Han, Sun, An, Lu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B-cell receptor and CD40-mediated cell signaling in Tespa1-deficient and wild-type (WT) B cells. (A) Levels of total and phosphorylated Lyn and Syk. (B) Levels of TNFR-associated factor (TRAF) 2, TRAF 3, and TRAF 6. (C) Levels of total and phosphorylated PLCγ2, BLNK, Btk, Grb2, and LAB. (D) Levels of total and phosphorylated Erk, p38, Jnk, Ikb, and Akt were measured by immunoblot. (E) TRAF 6 was normalized to GAPDH, Phospho-Plcγ2 and Phospho-ERK1/2 was normalized to total Plcγ2, and total ERK1/2 by densitometry statistical analysis. (F) Calcium flux was measured at the indicated times after stimulation. Data are from one experiment representative of three performed.