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. 2018 May 14;9:965. doi: 10.3389/fimmu.2018.00965

Figure 6.

Figure 6

Tespa1 deficiency significantly attenuates collagen-induced arthritis (CIA) in chimeric mice. (A) Incidence and clinical arthritis scores of Tespa1-deficient and WT chimeras following experimental induction of CIA. (B) Photographs and X-ray images of the hind limbs of WT and Tespa1-deficient chimeras 6 weeks after the first CII injection. (C) Microscopic sections of the knee joints of Tespa1-deficient and WT chimeras stained with H&E. Images are shown at 10× and 50× magnification. (D) Anti-collagen II IgG, IgG1, IgG2a, IgG2b, and IgG3 antibody levels in the sera of WT and Tespa1-deficient chimeras following CIA induction. Data shown are the mean ± SEM with 10 mice per group and are from one experiment, representative of two performed. *p < 0.05 and **p < 0.01 (Mann–Whitney test).