Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 14;11:158. doi: 10.3389/fnmol.2018.00158

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Siew and Chern.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Siglecs regulate microglial phagocytosis. Wild-type microglia express a low level of CD33/Siglec 3, a member of the Siglec family. The risk allele rs3865444 was originally identified in patients with Alzheimer’s disease (AD) and is associated with higher levels of CD33 that suppress the microglial phagocytosis. Conversely, knockdown of CD33 significantly improves the phagocytosis capability of microglia (Hollingworth et al., 2011; Naj et al., 2011; Griciuc et al., 2013). Aβ, amyloid β.