Table 5.
Summary of the role of Siglecs in neurological disease.
| Neurological conditions | Type of Siglec | Disease-associated features | References |
|---|---|---|---|
| Traumatic brain injury | Siglec-1 | • Up-regulated in the microglia upon exposure to plasma proteins, unclear function. | Perry et al. (1992) |
| Ceriod lipofuscinoses | Siglec-1 | • Up-regulated in the microglia of the optic nerve. | Groh et al. (2016) |
| • Serves as an APC and interacts with CD8+ T cells to promote inflammation. | |||
| Alzheimer’s disease | CD33 | • Up-regulated in the microglia to suppress phagocytosis of Aβ. | Bradshaw et al. (2013) and Griciuc et al. (2013) |
| Brain tumor | Siglec-H | • Phagocytosis of glioma cells | Kopatz et al. (2013) |
| Amyotrophic lateral sclerosis | Siglec-H | • Up-regulated over time in the spinal cord of SOD1 mice, uncharacterized function. | Chiu et al. (2013) |