Table 6.

Summary of the role of C-type lectins in neurological disease.

Neurological conditions	Type of C-type lectin	Disease-associated features	References
Stroke and ischemia	E-Selectin	Facilitates the adhesion of neutrophils to endothelial cells and promotes cell damage.	Zhang et al. (1996) and Jin et al. (2010)
	P-Selectin	Facilitates the adhesion of neutrophils to endothelial cells and promotes the activation of complement. Contributes to the breakdown of the BBB.	Atkinson et al. (2006) and Jin et al. (2010)
	Mannose-binding lectin	Up-regulated and contributes to cerebral infarction. Contributes to complement activation and promotes inflammation.	Cervera et al. (2010), Morrison et al. (2011), Orsini et al. (2012) and De Blasio et al. (2017)
Subarachnoid hemorrhage	P-Selectin	Recruits neutrophils and subsequently activates microglia through intravascular inflammation.	Atangana et al. (2017)
HIV infection	Mannose-binding lectin	Up-regulated in microglia, astrocytes, oligodendrocytes and neurons. Expression is associated with MCP-1, which may trigger inflammation.	Singh et al. (2011)