Table 2.
Biological process (BP) enriched categories obtained by Gene Ontology analysis.
| Biological process enriched category | Down-regulated genes | P adjusted | List of genes |
|---|---|---|---|
| Myelination | 7 | 0.004263845 | Pmp22, Serinc5, Ndrg1, Fa2 h, Mal, Rxrg, Egr2 |
| Positive regulation of ion transmembrane transport | 6 | 0.006544373 | Dmd, Hspa2, Snca, P2rx7, Atp1b2, Hcn1 |
| Glial cell differentiation | 8 | 0.008986003 | Gpr37l1, Ndrg1, Dmd, Epha4, Fa2 h, Egr2, Ntrk3, Lingo1 |
| Regulation of membrane potential | 9 | 0.010459252 | Dmd, Snca, P2rx7, Grik2, Atp1b2, Kcnk5, Cldn19, Slc26a2, Hcn1 |
| Bleb assembly | 3 | 0.023620351 | Emp2, Pmp22, P2rx7 |
| Positive regulation of apoptotic process | 11 | 0.080348376 | Atf3, Bmf, Gadd45a, Ctsc, Snca, P2rx7, Grik2, Mal, Fbxo32, Ntrk3, Sept4 |
| Macrophage activation | 3 | 0.095570035 | Cd200, Snca, Adgrf5 |
| Biological process enriched category | Up-regulated genes | P adjusted | List of genes |
| rRNA metabolic processes | 11 | 0.000126 | Fbl, Bop1, Wdr46, Nop56, Ddx21, Nat10, Bysl, Rrp9, Nop2, Emg1, Rrp15 |
| Negative regulation of Notch signalling pathway | 4 | 0.02191 | Bmp7, Dlk1, Lfng, Dll4 |
Because of redundancy in gene ontology annotations, only a selected list of up-regulated and down-regulated biological processes is shown (all enriched categories of biological processes, molecular functions and cellular components are shown in Supplementary Table S2).