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. 2018 May 14;9:933. doi: 10.3389/fimmu.2018.00933

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Copyright © 2018 Butcher, O’Carroll, Wells and Carmody.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ligand-specific patterns of super-induction on toll-like receptor (TLR) re-stimulation. Probes showing super-induction in at least one infection were clustered using partitioning around medoids. Heat maps for each cluster. Color indicates row z-score of mean log₂ expression. Columns (L–R) naïve, lipopolysaccharide acute, and restimulation; CpG acute, restimulation; Pam3csk4 acute, restimulation; Poly(I:C) acute, restimulation. Pearson correlation of z scores shown in rows. Significantly enriched pathways, grouped thematically. Maximum adjusted p-value for all pathways significantly enriched in that theme is shown. Transcription factor binding motifs enriched in each cluster. Motif logos and p-values are representative for each transcription factor family. Full motif enrichment results are available at www.stemformatics.org.