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. 2018 May 14;9:463. doi: 10.3389/fphar.2018.00463

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Copyright © 2018 Ripperger, Krischer, Robaa, Sippl and Benndorf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PhA efflux assay: concentration-dependent inhibition of ABCG2-mediated PhA efflux by telmisartan (A,B), candesartan cilexetil (C,D), and irbesartan (E,F) in HEK293-Tet-On cells transiently transfected with ABCG2 WT or ABCG2 variants (Y469A, M483F, and Y570A), respectively. Data are shown as mean ± SD (n = 4–14). ^∗P < 0.05 vs. WT. Representative flow cytometric plots of genotype-specific telmisartan- (B), candesartanclexetil- (D), and irbesartan (F)-related inhibition of ABCG2-mediated PhA efflux.