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. 2018 Winter;19(1):9–14.

Table 2.

Pharmacokinetic parameters of FFC following-oral administration in broiler chickens a

Parameter Unit FFC + SAL FFC + FLU FFC + KET FFC + VER
A µg/ml 15.17 ± 0.70 16.21 ± 1.84 25.73 ± 2.23** 16.52 ± 0.31
t1/2ka h 0.51 ± 0.03 0.66 ± 0.04* 0.59 ± 0.02 0.42 ± 0.003
t1/2ke h 1.14 ± 0.14 1.41 ± 0.02 1.55 ± 0.12* 1.09 ± 0.02
Tmax h 1.07 ± 0.09 1.35 ± 0.05** 1.32 ± 0.03* 0.94 ± 0.001
Cmax µg/ml 4.33 ± 0.33 4.44 ± 0.26 8.66 ± 0.18** 5.55 ± 0.22**
AUC mg·h/L 13.8 ± 2.18 17.62 ± 1.51 35.04 ± 2.11** 15.96 ± 0.80
CL/Fs L/kg·h 2.28 ± 0.34 1.73 ± 0.14 0.86 ± 0.06** 1.89 ± 0.10
V/F L/kg 3.63 ± 0.19 3.51 ± 0.25 1.91 ± 0.03** 2.97 ± 0.10*
a

Note: FFC (30 mg/kg b.wt.) was co-administered orally with SAL, FLU (60 mg/kg), KET (25 mg/kg) or VER (9 mg/kg) (mean±SE, n=6) (mean±SE, n=6).

*

P<0.05 and

**

P<0.01 compared with the FFC + SAL group