Table 2.
Parameter | Unit | FFC + SAL | FFC + FLU | FFC + KET | FFC + VER |
---|---|---|---|---|---|
A | µg/ml | 15.17 ± 0.70 | 16.21 ± 1.84 | 25.73 ± 2.23** | 16.52 ± 0.31 |
t1/2ka | h | 0.51 ± 0.03 | 0.66 ± 0.04* | 0.59 ± 0.02 | 0.42 ± 0.003 |
t1/2ke | h | 1.14 ± 0.14 | 1.41 ± 0.02 | 1.55 ± 0.12* | 1.09 ± 0.02 |
Tmax | h | 1.07 ± 0.09 | 1.35 ± 0.05** | 1.32 ± 0.03* | 0.94 ± 0.001 |
Cmax | µg/ml | 4.33 ± 0.33 | 4.44 ± 0.26 | 8.66 ± 0.18** | 5.55 ± 0.22** |
AUC | mg·h/L | 13.8 ± 2.18 | 17.62 ± 1.51 | 35.04 ± 2.11** | 15.96 ± 0.80 |
CL/Fs | L/kg·h | 2.28 ± 0.34 | 1.73 ± 0.14 | 0.86 ± 0.06** | 1.89 ± 0.10 |
V/F | L/kg | 3.63 ± 0.19 | 3.51 ± 0.25 | 1.91 ± 0.03** | 2.97 ± 0.10* |
Note: FFC (30 mg/kg b.wt.) was co-administered orally with SAL, FLU (60 mg/kg), KET (25 mg/kg) or VER (9 mg/kg) (mean±SE, n=6) (mean±SE, n=6).
P<0.05 and
P<0.01 compared with the FFC + SAL group