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. Author manuscript; available in PMC: 2018 Oct 19.
Published in final edited form as: Cell. 2017 Oct 19;171(3):501–502. doi: 10.1016/j.cell.2017.10.006

Figure 1. PEBP1 associates with lipoxygenases and allows them to generate a specific lipid peroxide that promotes ferroptosis.

Figure 1

(a) The unbound enzyme acts on free fatty acids. (b) Bound to PEBP1, lipoxygenases acquire the ability to convert membrane phosphatidylethanolamine (PE) to its oxidized form, leading to ferroptotic cell death.