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. 2018 May 21;24(19):2095–2107. doi: 10.3748/wjg.v24.i19.2095

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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Sliding window analysis of the nucleotide region of interest in the hepatitis B virus X gene (nt 1255-1611). Each point on the graph is the result of the mean information content (IC, bits) of the windows 25-nt in size, with displacement between them in 1-nt steps. The purple line represents the mean IC from the multiple alignments of all haplotypes (in abundance > 0.25%) in the quasispecies (QS) of all patients (n = 720), whereas the blue line shows the mean IC obtained from the multiple alignments of the consensus obtained for each patient (n = 27).