Table 1.
Proteins increased by DMXAA stimulation on secretome analysis
Proteins increased by more than 4-fold with high significance (q < 0.05) are listed.
| Gene symbol | Description | No. of PSMsa | No. of peptides | % Coverage | -Fold increase DMXAA/DMSO |
|---|---|---|---|---|---|
| Ccl4 | C-C motif chemokine 4 | 914 | 6 | 55 | 80.1 |
| Tnf | Tumor necrosis factor | 424 | 13 | 58 | 141.9 |
| Glg1 | Golgi apparatus protein 1 | 264 | 42 | 45 | 9.4 |
| Sema4d | Semaphorin 4D | 218 | 20 | 31 | 4.3 |
| Sdc4 | Syndecan-4 | 168 | 5 | 22 | 22.3 |
| Mthfd1 | C-1-tetrahydrofolate synthase, cytoplasmic | 140 | 28 | 41 | 5.0 |
| H2-T23 | H-2 class I histocompatibility antigen, d-37 α-chain | 55 | 3 | 19 | 5.6 |
| Cxcl10 | C-X-C motif chemokine 10 | 45 | 5 | 34 | 94.2 |
| Ccl2 | C-C motif chemokine 2 | 45 | 4 | 21 | 8.4 |
| Fam3c | Protein FAM3C | 36 | 5 | 26 | 6.6 |
| Hist1h1d | Histone H1.3 | 25 | 1 | 26 | 5.0 |
| Tor3a | Torsin 3A | 23 | 5 | 18 | 6.0 |
| Ifnb1 | Interferon β | 18 | 4 | 18 | 28.0 |
| Lrpap1 | α-2-Macroglobulin receptor-associated protein | 14 | 4 | 12 | 5.9 |
| Cxcl2 | C-X-C motif chemokine 2 | 13 | 2 | 36 | 18.9 |
| Ccl5 | C-C motif chemokine 5 | 7 | 2 | 21 | 41.9 |
| Icam2 | Intercellular adhesion molecule 2 | 7 | 2 | 6 | 4.8 |
| Golim4 | Golgi integral membrane protein 4 | 6 | 4 | 10 | 4.2 |
| Acvr1 | Activin receptor type-1 | 6 | 1 | 2 | 6.4 |
| Lif | Leukemia inhibitory factor | 5 | 1 | 5 | 8.3 |
| Ube2d3 | Ubiquitin-conjugating enzyme E2 D3 | 4 | 2 | 29 | 19.7 |
| Qsox2 | Sulfhydryl oxidase 2 | 4 | 3 | 6 | 4.4 |
| Lrig2 | Leucine-rich repeats and immunoglobulin-like domains protein 2 | 1 | 1 | 2 | 4.7 |
a PSM, peptide spectrum match.