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. 2018 Apr 5;27(11):2012–2024. doi: 10.1093/hmg/ddy109

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Figure 1. — Generation of the Ift172^fl/fliCre mouse model and of the IFT172 antibody. (A) Schematic representation of the targeted Ift172 allele (Ift172^fl/fl) and the knock-out allele (Ift172^fl/fliCre). (B) Expression of Cre recombinase (red) in the ONL at postnatal days 18, 21 and 25. Nuclei are counterstained with Hoechst (blue). The scale bar represents 10 μm. (C) Schematic representation of human IFT172 protein, containing repetitive W40 and TPR motifs. A total of 488 carboxyl terminal amino acid residues were chosen for the rabbit polyclonal antibody generation. (D) Staining for IFT172 (red) and RP1 (green) at postnatal days 21, 25 and 28 showing depletion of IFT172 from rods by P28 in Ift172^fl/fliCre mice. The scale bar represents 5 μm.