Figure 4.
Human GR domain structure and sites of post-translational modification.38 Reprinted from Oakley RH, Cidlowski JA. The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease. J Allergy Clin Immunol. 2013;132:1033–1044. Published by Elsevier. The regions of the receptor involved in transactivation (AF1 and AF2), dimerization, nuclear localization, and hsp90 binding are indicated, as are the sites modified by phosphorylation (P), sumoylation (S), ubiquitination (U), and acetylation (A).