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The 3D and secondary structures of two internal loops in a 18S rRNA and a Cas9–sgRNA–DNA complex. (A) and (B) are the 3D structures of two loops in the 18S rRNA (PDB ID: 3U5F, chain: 6) and the sgRNA (PDB ID: 4OO8, chain: B). The extended regions are shown in gray. (C) and (D) are the secondary structures of (A) and (B). In (A–D), the nucleotides binding with the proteins are marked in red.
