Table 2.

Genome-wide-significant loci from the discovery meta-analysis in all individuals for left hand 2D:4D ratio; the most significant SNP from each locus is presented

	Chr	Position [bp (GRCh37/hg19)]	Nearest gene	Effect allele/ other allele	EAFa	Beta	SE	P-value
rs4927012
Discovery	1	54068016	GLIS1	T/C	0.875	−0.358	0.058	5.08 × 10−10
Replication	1	54068016	GLIS1	T/C	0.871	−0.042	0.006	3.48 × 10−12
rs11581730
Discovery	1	155082158	EFNA1	A/T	0.496	0.294	0.036	3.02 × 10−16
Replication	1	155082158	EFNA1	A/T	0.503	0.026	0.004	4.99 × 10−11
rs340600
Discovery	2	20892006	LDAHb	T/G	0.199	−0.379	0.046	1.38 × 10−16
Replication	2	20892006	LDAHb	T/G	0.199	−0.043	0.005	1.81 × 10−17
rs12474669
Discovery	2	175134232	OLA1	A/G	0.139	0.417	0.054	1.51 × 10−14
Replication	2	175134232	OLA1	A/G	0.143	0.043	0.006	1.92 × 10−13
rs847158
Discovery	2	176962102	HOXD12/HOXD11	A/G	0.602	0.199	0.037	1.03 × 10−7
Replication	2	176962102	HOXD12/HOXD11	A/G	0.609	0.039	0.004	3.04 × 10−20
rs314277c
Discovery	6	105407662	LIN28B	A/C	0.155	0.428	0.050	5.55 × 10−18
Replication	6	105407662	LIN28B	A/C	0.149	0.067	0.006	1.77 × 10−32
rs77640775d
Discovery	7	42190714	GLI3	A/G	0.137	−0.252	0.053	1.92 × 10−6
Replication	7	42190714	GLI3	A/G	0.146	−0.033	0.006	6.64 × 10−9
rs10790969
Discovery	11	128529842	FLI1	T/C	0.276	0.284	0.040	1.33 × 10−12
Replication	11	128529842	FLI1	T/C	0.272	0.027	0.005	1.26 × 10−9
rs2332175c
Discovery	14	70345411	SMOC1	A/G	0.529	0.360	0.037	3.00 × 10−22
Replication	14	70345411	SMOC1	A/G	0.546	0.045	0.004	6.74 × 10−29
rs6499762
Discovery	16	51697874	SALL1	A/C	0.125	0.441	0.056	5.33 × 10−15
Replication	16	51697874	SALL1	A/C	0.129	0.083	0.006	2.83 × 10−41
rs1080014
Discovery	16	51900171	TOX3	C/T	0.514	0.203	0.036	1.94 × 10−8
Replication	16	51900171	TOX3	C/T	0.501	0.012	0.004	3.35 × 10−3
rs4799176
Discovery	18	76378307	SALL3	C/T	0.256	0.305	0.044	4.09 × 10−12
Replication	18	76378307	SALL3	C/T	0.244	0.057	0.005	1.89 × 10−34

Replication results are presented from 23andMe where the 2D:4D ratio was reported as a relative measure [i.e. 0 = index finger longer (17.1% of research participants), 1 = index and ring finger the same length (14.0% of research participants), 2 = ring finger longer (68.9% of research participants)].

^aAverage effect allele frequency (EAF) across the cohorts in each of the meta-analyses.

^bPreviously known as C2orf43.

^cGenetic loci that had previously been associated with 2D:4D ratio in Medland et al. (30).

^dSNP passed genome-wide significance in the average 2D:4D ratio meta-analysis (see Supplementary Material for results).