Table 2.
Retention, Compliance, and Participant Characteristicsa by Randomization Arm and Vaccination Status: STRIVE (n = 8626)
| Study Variable | Immediate Vaccination (N = 4311) n (%) |
Deferred Vaccination (N = 4315) n (%) |
Crossoverb (N = 3810) n (%) |
All Vaccinated (N = 7979) n (%) |
All Randomized (N = 8626) n (%) |
|---|---|---|---|---|---|
| Retained | 4104 (95.2) c | 3875 (89.8) | 3628 (95.2)d | 7649 (95.9)d | 7979 (92.5) |
| Fully Compliant | 3165 (73.4) | 2769 (64.2) | 2455 (64.4) | 5620 (70.4) | 5934 (68.8) |
| Male Gender | 2611 (60.6) | 2617 (60.6) | 2454 (64.4) | 5032 (63.1) | 5228 (60.6) |
| Age (Tertiled) (years) | |||||
| 18–27 | 1423 (33.0) | 1452 (33.7) | 1283 (33.7) | 2658 (33.3) | 2875 (33.3) |
| 28–35 | 1470 (34.1) | 1406 (32.6) | 1213 (31.8) | 2619 (32.8) | 2876 (33.3) |
| >35 | 1418 (32.9) | 1457 (33.8) | 1314 (34.5) | 2702 (33.9) | 2875 (33.3) |
| Primary Occupation | |||||
| Nursee | 1443 (33.5) | 1428 (33.1) | 988 (25.9) | 2336 (29.3) | 2871 (33.3) |
| Doctor | 13 (0.3) | 11 (0.3) | 7 (0.2) | 20 (0.3) | 24 (0.3) |
| Pharmacist | 20 (0.5) | 19 (0.4) | 19 (0.5) | 39 (0.5) | 39 (0.5) |
| Allied health professionalf | 77 (1.8) | 72 (1.7) | 58 (1.5) | 130 (1.6) | 149 (1.7) |
| Community health worker | 85 (2.0) | 93 (2.2) | 68 (1.8) | 153 (1.9) | 178 (2.1) |
| Laboratory worker | 133 (3.1) | 139 (3.2) | 139 (3.6) | 269 (3.4) | 272 (3.2) |
| Frontline workerg | 2065 (47.9) | 2089 (48.4) | 1340 (35.2) | 3377 (42.3) | 4154 (48.2) |
| Surveillance worker | 246 (5.7) | 250 (5.8) | 170 (4.5) | 410 (5.1) | 496 (5.8) |
| Other/Not reported | 229 (5.3) | 214 (5.0) | 128 (3.4) | 352 (4.4) | 443 (5.1) |
| Facility Type | |||||
| Clinic setting | 796 (18.5) | 794 (18.4) | 837 (22.0) | 1626 (20.4) | 1590 (18.4) |
| Ebola Facility | 1491 (34.6) | 1493 (34.6) | 686 (18.0) | 2119 (26.6) | 2984 (34.6) |
| Hospital | 1722 (39.9) | 1711 (39.7) | 1365 (35.8) | 3020 (37.8) | 3433 (39.8) |
| Other/Not reported | 302 (7.0) | 317 (7.3) | 922 (24.2) | 1214 (15.2) | 619 (7.2) |
| Education | |||||
| Tertiary | 1810 (42.0) | 1778 (41.2) | 1500 (39.4) | 3209 (40.2) | 3588 (41.6) |
| Secondary | 1874 (43.5) | 1937 (44.9) | 1773 (46.5) | 3614 (45.3) | 3811 (44.2) |
| Primary | 233 (5.4) | 216 (5.0) | 191 (5.0) | 420 (5.3) | 449 (5.2) |
| None | 374 (8.7) | 363 (8.4) | 338 (8.9) | 709 (8.9) | 737 (8.5) |
| Other/Not reported | 20 (0.5) | 21 (0.5) | 8 (0.2) | 27 (0.3) | 41 (0.5) |
| Enrollment Site District (Town) | |||||
| Western Area Rural | 941 (21.8) | 949 (22.0) | 849 (22.3) | 1746 (21.9) | 1890 (21.9) |
| Western Area Urban | 1624 (37.7) | 1620 (37.5) | 1370 (36.0) | 2915 (36.5) | 3244 (37.6) |
| Bombali | 599 (13.9) | 603 (14.0) | 544 (14.3) | 1137 (14.2) | 1202 (13.9) |
| Tonkolili | 366 (8.5) | 365 (8.5) | 338 (8.9) | 703 (8.8) | 731 (8.5) |
| Port Loko (Port Loko Town) | 433 (10.0) | 429 (9.9) | 398 (10.4) | 823 (10.3) | 862 (10.0) |
| Port Loko (Lunsar) | 197 (4.6) | 199 (4.6) | 172 (4.5) | 365 (4.6) | 396 (4.6) |
| Port Loko (Kaffu Bullom) | 151 (3.5) | 150 (3.5) | 139 (3.6) | 290 (3.6) | 301 (3.5) |
Abbreviation: STRIVE, Sierra Leone Trial to Introduce a Vaccine Against Ebola.
aThere were no significant differences in demographic characteristics between the participants randomized to the immediate and deferred vaccination arms.
bParticipants randomized to deferred vaccination arm who were vaccinated 18–24 weeks after enrollment.
cParticipants randomized to immediate vaccination who were retained 6 months after enrollment.
dParticipants who were retained 6 months after vaccination.
eIncludes nurse, midwife, community health nurse, nursing aide, maternal-child health aide, nursing student, and vaccinator.
fIncludes dentist, medical counselor, nutritionist, and physiotherapist.
gIncludes contact tracers, ambulance crew, burial workers, cleaners, and swabber (persons taking postmortem skin/mucosal swabs for Ebola testing).