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. 2018 May 18;4(3):e239. doi: 10.1212/NXG.0000000000000239

Figure 2. Flow chart of patients who met the inclusion/exclusion criteria for the study.

Figure 2

(A) All patients with ALS registered with the Irish ALS register from 1994 to 2016 who reported a history of suspected or confirmed ALS or FTD in at least 1 relative were identified. All patients with an established, highly penetrant ALS variant (C9orf72 89, TARDBP 1, FUS 2, SOD1 1, and SQSTM1 1) were identified from the DNA database. (B) Thirty-five patients with a family history suspicious for ALS or FTD in whom it was not possible to confirm the relatives' diagnoses and 9 patients with Kennedy disease were excluded. Five C9orf72-positive patients with a family history suspicious for ALS or FTD in whom it was not possible to confirm the relatives' diagnoses were recategorized into gene-positive only category. ALS = amyotrophic lateral sclerosis; FTD = frontotemporal lobar dementia.