Figure 2.

Resveratrol sensitized MM cells to CFZ-induced apoptosis. (A), LP-1 and MM.1S cells were treated with RSV (50 μM), CFZ (40 nM), or in a combination of them for 24 h. FITC-Annexin V staining was detected through flow cytometry. (B), Cells of four MM cell lines (LP-1, U266, MM.1S, and MM.1R) were treated with RSV (50 μM), CFZ (40 nM), or in a combination of them for 24 h. Data represent the mean ± SD for three separate experiments performed in triplicate. #P < 0.01, CFZ+RSV groups vs single agent treated groups as indicated. (C), LP-1 and MM.1S cells were treated with RSV (50 μM), CFZ (40 nM) or their combination for 24 h. Cleaved PARP and caspase−3/−9 were detected by Western blotting. Tubulin was used as a loading control.