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. 2018 Apr 18;29(5):1141–1153. doi: 10.1093/annonc/mdy114

Table 3.

Summary table of nutritional goals, achieved intakes and compliance data for studies conducted with DC and/or high-energy ONS

Values in parentheses were calculated from published dataa
 Energy intake
 Protein intake
 Information on compliance
Study Summary intervention Intake at baseline Study goal Achieved intake after intervention Intake at baseline Study goal Achieved intake after intervention Compliance Consumption of ONS
Elkort [36] high-energy ONS NR Meet requirements according to RDA 1974 NR NR Meet/exceed requirements according to RDA 1974 NR Compliance records were monitored and home visits were planned as needed, but no record of actual compliance NR
Evans [29] DC+high- energy ONS NR

  • TCI=1.7 or 1.95×BEE depending on nutritional status at inclusion

  • (2486 or 2850 kcal/day)

  • 90% of TCI

  • (2237 or 2565 kcal/day)

 NR

  • 12.5 or 25% of energy as protein

  • (∼80 g or 160 g/day)

 NR Tube feeding was indicated for 68% of patients but provided to only 6% (high refusal rate) NR
Ovesen [39] DC+high- energy ONS if required

  • 1839 kcal/day

  • (26.3 kcal/kg/day)

 1.5–1.7×BEE (2103–2383 kcal/day)

  • 1982 kcal/day

  • (28.3 kcal/kg/day)

  • 61 g/day

  • (0.87 g/kg/day)

  • 1–1.2 g/kg/day

  • (70–84 g/day)

  • 69 g/day

  • (0.9 g/kg/day)

 Achieved intake was close to targets, but remained lower i.e. 1.5 × BEE and 0.9 g/kg protein 21% of patients
Breitkreutz [37] high-energy ONS NR

  • 35 non protein kcal/kg/day

  • (2758 kcal/day)

  • (1865 kcal/day)

  • (26.6 kcal/kg/day)

 NR

  • 1.1 g/kg/day

  • (77 g/day)

 NR NR NR
Baldwin [30] DC and/or high-energy ONS NR

  • +600 kcal/day, or

  • + 600 kcal/day and supplements

 NR NR – NR Not enough food diaries returned to be analyzed. Compliance to ONS fell after one week At the end of intervention, 19% of patients reported to consume all prescribed ONS
Bourdel Marchasson [26] DC+high- energy ONS if required

  • 1384 kcal/day

  • (19.8 kcal/kg/day)

  • 30 kcal/kg/day

  • (2100 kcal/day)

  • 1700 kcal/day

  • (24.3 kcal/kg/day)

  • 64.7 g/day

  • (0.9 g/kg/day)

  • 1.2 g/kg/day

  • (84 g/day)

  • 79.7 g/day

  • (1.1 g/kg/day)

 At visit 2, energy goals were reached by 40% and protein goals by 47% of patients Up to 25% of patients
a

In order to provide a better visualization beyond the heterogeneity in the type of information available, values in parentheses were calculated from available published data. Calculations were made for a ‘standard person’ with a body weight of 70 kg and a height of 1.70 m.

ONS, oral nutritional supplement; NR, not reported; RDA, recommended daily amount; DC, dietary counseling; TCI, total caloric intake; BEE, basal energy expenditure.