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. 2018 Apr 14;46(9):4689–4698. doi: 10.1093/nar/gky272

Figure 4.

Figure 4.

Model for the RPA effects on WRN helicase activity. In the model, binding of multiple RPAs converts WRN into a superhelicase, but the oligomeric state of active WRN is not fixed. Therefore, multiple RPA binding can occur either to a single WRN, or an oligomeric WRN even though the two possibilities are not mutually exclusive.