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. 2018 Feb 26;46(9):4382–4391. doi: 10.1093/nar/gky147

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Spatial segregation of CGI+ and CGI− genes. (A) CGI-centered regulation mechanisms in CGI+ genes, and (B) heterochromatin features in CGI− genes. All protein coding genes are sorted by their expression values (left blue line plot), and the genomic landscape of promoter surrounding regions are shown. (C) CGI-guided chromosomal architecture model. (D) Association of peripheral nuclear lamina (LMNB1) with silent CGI− genes, but not CGI+ genes. (E) Localization of single CGI+ (or CGI−) gene cluster in fibroblasts and myotubes, and (F) multiple silent CGI+/CGI− gene clusters in fibroblasts (eight clusters each) determined by 3D FISH. Percentages of gene loci located in the nuclear center compared to the periphery in each cell are shown in bottom right. P-values: Wilcoxon signed-rank tests. Scale bar: 5 μm. Error bars show S.E.M.