Table 1. Summary of CGI-dependent chromosomal architectures and gene regulations.

	CGI− genes	CGI+ genes
Gene regulation	Local enhancer-loop model	3D long-range interaction network model
Chromatin status	Heterochromatin—Euchromatin	Euchromatin
Chromosomal architectures	Chromosomal territory (CT)-extrusion model	Nuclear subcompartment model
Default gene location in nucleus	Nuclear periphery (extruded into the center when activated)	Nuclear center (regardless of the gene activity)
Dimension of regulationa	Linear local regulation	3D spatial regulation
Nuclear landscape modelb	Chromosomal territory-interchromatin compartment (CT-IC) model	Interchromatin network (ICN) model

^aSee also Supplementary Figure S6.

^bDiscussed in Supplementary Figure S7.