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. 2018 Mar 5;46(9):e57. doi: 10.1093/nar/gky152

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Five regulatory elements controlling HIV-1 replication. gRNA production is positively regulated by sequences within TAR and by the U1snRNP binding site within SL2. gRNA production is negatively regulated by the AAUAAA motif in 5′ polyA. The U1snRNP binding site is required for repression of 5′ polyadenylation. gRNA packaging into virions requires both the Pr55^Gag binding site (SL1-SL3), and the AAUAAA motif in 5′ PolyA. Positive regulatory elements are highlighted in green. Negative regulatory elements are highlighted in red.