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. 2018 Apr 17;46(9):4370–4381. doi: 10.1093/nar/gky271

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Pathway enrichment analysis for genes with low (bottom 5% genes), intermediate (mid 50–60%), and high (top 5% genes) unexplained variance in gene expression across all cancers. ECM remodeling and GPCR signaling pathways were consistently significant across almost all cancer types in top 5% genes (low PVE) genes, whereas bottom 5% genes (high PVE) show almost exclusive enrichment for cell cycle related pathways. Color intensity represents –log₁₀(FDR-p.value). Dark blue color represents significance.