Table 2.

Incidence rate and HR for acute pancreatitis by study cohort, overall and stratified by follow-up time

Analysis	Cohort	No. of patients	AP events	Follow-up years		AP rate per 1,000 person-years (95% CI)	HR (95% CI)
				Total	Median (IQR)		Crude	Weighted
Overall
	DPP-4I	49,374	150	74,021	1.05 (0.60–2.03)	2.0 (1.7–2.4)	1.00 (0.83–1.20)	1.01 (0.83–1.24)
	SU	132,223	467	230,484	1.24 (0.67–2.43)	2.0 (1.9–2.2)	1.00	1.00
Stratified by follow-up time
0–1 year	DPP-4I	49,374	70	39,207	1.00 (0.60–1.00)	1.8 (1.4–2.3)	0.89 (0.68–1.17)	0.94 (0.70–1.25)
	SU	132,223	218	108,823	1.00 (0.67–1.00)	2.0 (1.8–2.3)	1.00	1.00
1–2 years	DPP-4I	25,636	44	18,255	0.97 (0.40–1.00)	2.4 (1.8–3.2)	1.09 (0.78–1.54)	1.07 (0.73–1.56)
	SU	76,329	126	57,109	1.00 (0.48–1.00)	2.2 (1.9–2.6)	1.00	1.00
>2 years	DPP-4I	12,551	36	16,559	0.97 (0.45–1.88)	2.2 (1.6–3.0)	1.14 (0.79–1.65)	1.11 (0.74–1.67)
	SU	41,304	123	64,553	1.24 (0.55–2.35)	1.9 (1.6–2.3)	1.00	1.00
Overall
	DPP-4I	57,301	159	86,795	1.07 (0.64–2.03)	1.8 (1.6–2.1)	1.11 (0.85–1.43)	1.11 (0.76–1.62)
	TZD	32,612	87	52,383	1.14 (0.70–2.09)	1.7 (1.3–2.0)	1.00	1.00
Stratified by follow-up time
0–1 year	DPP-4I	57,301	84	46,007	1.00 (0.64–1.00)	1.8 (1.5–2.3)	1.19 (0.82–1.73)	1.19 (0.71–2.01)
	TZD	32,612	42	27,433	1.00 (0.70–1.00)	1.5 (1.1–2.1)	1.00	1.00
1–2 years	DPP-4I	30,289	39	21,382	0.94 (0.39–1.00)	1.8 (1.3–2.5)	1.22 (0.71–2.12)	1.05 (0.46–2.43)
	TZD	18,215	19	12,741	0.93 (0.36–1.00)	1.5 (1.0–2.3)	1.00	1.00
>2 years	DPP-4I	14,537	36	19,406	0.99 (0.45–1.90)	1.9 (1.3–2.6)	0.87 (0.52–1.44)	0.93 (0.50–1.74)
	TZD	8,672	26	12,209	1.08 (0.45–2.02)	2.1 (1.5–3.1)	1.00	1.00

AP, acute pancreatitis; IQR, interquartile range; SU, sulfonylurea.