Table 2.

Associations of MS at baseline with baseline ALT values and APRI scores using multivariable analysis

Variables	Baseline ALT (n = 734)			Baseline APRI score (n= 687)
	Ratio*	95% CI	P value	Ratio*	95% CI	P value
MS (vs. no MS)	1.10	0.97–1.26	0.14	0.89	0.79–1.02	0.09
Age, per decade (years)	0.99	0.95–1.04	0.69	1.08	1.03–1.13	0.0006
Female sex (vs. male sex)	0.70	0.63–0.77	<0.0001	0.76	0.69–0.84	<0.0001
Race (vs. white)
Asian	0.93	0.79–1.10	0.39	0.91	0.77–1.07	0.24
Black	0.84	0.69–1.03	0.09	0.90	0.73–1.10	0.29
Other	0.83	0.61–1.14	0.25	0.92	0.68–1.26	0.61
Alcohol use in past 12 months (vs. none)
Moderate	1.00	0.91–1.09	0.97	1.06	0.93–1.19	0.39
At risk	1.04	0.90–1.20	0.62	1.05	0.86–1.28	0.66
Birth and immigration status (vs. foreign-born and immigrated ≤20 years ago)
Born in U.S./Canada or foreign-born and immigrated >20 years ago	0.94	0.85–1.05	0.29	0.92	0.83–1.02	0.10
Foreign-born but unknown date of immigration	1.03	0.79–1.33	0.85	1.02	0.80–1.30	0.89
Family history of diabetes (vs. none)	1.08	0.98–1.20	0.12	1.01	0.91–1.12	0.87
Log10HBV DNA (IU/mL)	1.14	1.11–1.18	<0.0001	1.10	1.07–1.14	<0.0001
HBeAg positive (vs. negative)	0.93	0.79–1.10	0.39	1.07	0.91–1.25	0.44

*Factor by which the mean ALT value or APRI score differs for the comparator vs. the reference. For example, the baseline ALT in women is, on average, 70% of that in men with all other factors kept constant, and the mean baseline APRI is 10% higher in people with a 1 log₁₀ higher HBV DNA level.