Table 3.
Associations of MS at baseline with baseline and longitudinal ALT values and APRI scores using multivariable analysis*
| Variables | Baseline and longitudinal ALT levels (n = 734) |
Baseline and longitudinal APRI scores (n = 687) |
||||
|---|---|---|---|---|---|---|
| Ratio† | 95% CI | P value | Ratio† | 95% CI | P value | |
| MS (vs. no MS) | 1.12 | 1.02–1.22 | 0.02 | 0.91 | 0.82–1.01 | 0.06 |
| Age, per decade (years) | 1.00 | 0.97–1.03 | 0.87 | 1.08 | 1.04–1.12 | <0.0001 |
| Female sex (vs. male sex) | 0.73 | 0.68–0.78 | <0.0001 | 0.81 | 0.76–0.88 | <0.0001 |
| Race (vs. white) | ||||||
| Asian | 0.89 | 0.79–1.00 | 0.052 | 0.81 | 0.77–0.99 | 0.03 |
| Black | 0.87 | 0.75–1.00 | 0.056 | 0.84 | 0.71–0.98 | 0.03 |
| Other | 0.94 | 0.76–1.17 | 0.59 | 0.99 | 0.78–1.26 | 0.95 |
| Alcohol use in past 12 months (vs. none) | ||||||
| Moderate | 1.00 | 0.92–1.10 | 0.92 | 1.01 | 0.92–1.11 | 0.84 |
| At risk | 1.05 | 0.91–1.21 | 0.52 | 1.03 | 0.88–1.21 | 0.67 |
| Birth/immigration status (vs. foreign-born and immigrated ≤20 years ago) | ||||||
| Born in U.S./Canada or foreign-born and immigrated >20 years ago | 0.95 | 0.88–1.03 | 0.20 | 0.99 | 0.91–1.07 | 0.71 |
| Foreign-born but unknown date of immigration | 0.98 | 0.81–1.18 | 0.83 | 0.94 | 0.77–1.14 | 0.53 |
| Family history of diabetes (vs. none) | 1.03 | 0.96–1.11 | 0.36 | 0.98 | 0.91–1.06 | 0.65 |
| Log10 HBV DNA (IU/mL)‡ | 1.21 | 1.20–1.22 | <0.0001 | 1.16 | 1.15–1.18 | <0.0001 |
| HBeAg positive (vs. negative) | 0.85 | 0.78–0.93 | 0.0006 | 0.91 | 0.82–1.00 | 0.0500 |
*Analysis was also controlled for duration of follow-up, receipt of HBV therapy, and duration of HBV therapy.
†Factor by which the mean ALT value or APRI score differs for the comparator vs. the reference.
‡Measured at baseline and longitudinally.