Figure 6.

Neuroclinical correlation maps. Left: The duration of disease in patients with type 1 diabetes was significantly correlated with response amplitude across the encoding and maintenance periods in two distinct regions. The right temporoparietal negative correlation (peak voxel: r = −0.52, P = 0.003) with disease duration likely reflects compensatory activity in right hemispheric homolog areas, which gets stronger with longer disease duration. However, the negative correlation between parieto-occipital activity and time since diagnosis (peak voxel: r = −0.48, P = 0.005) likely reflects aberrantly decreased occipital inhibition with disease progression. Right: The HbA_1c level in patients was negatively correlated with right parietal activity during encoding and maintenance (peak voxel: r = −0.52, P = 0.002), such that as HbA_1c levels increased, there were greater decreases in alpha relative to the baseline, again suggesting compensatory activity. All correlations were performed using age as a covariate of no interest, because it was found to correlate with both disease duration and HbA_1c levels. L, left; R, right.