Table 2.

Arterial concentrations (µmol/L) and net hepatic balances (µmol/kg/min) of lactate, alanine, βOHB, glycerol, and NEFA

Parameter and treatment	Basal	P1	P2
Arterial blood lactate
Control	467 ± 61	393 ± 42	603 ± 42
GRI-630	466 ± 51	378 ± 36	544 ± 30
Net hepatic lactate output
Control	8.2 ± 6.4	5.9 ± 3.5	10.1 ± 2.3
GRI-630	4.2 ± 2.2	5.5 ± 1.5	10.7 ± 1.4
Arterial blood alanine
Control	310 ± 35	307 ± 29	337 ± 28
GRI-630	302 ± 23	312 ± 19	330 ± 29
Net hepatic alanine  uptake
Control	2.2 ± 0.3	1.6 ± 0.2	1.4 ± 0.3
GRI-630	2.1 ± 0.2	1.7 ± 0.2	1.7 ± 0.2
Arterial blood βOHB
Control	25 ± 2	19 ± 2	13 ± 2
GRI-630	23 ± 2	17 ± 1	11 ± 1
Net hepatic βOHB output
Control	0.4 ± 0.1	0.3 ± 0.1	0.1 ± 0.0
GRI-630	0.6 ± 0.2	0.3 ± 0.1	0.1 ± 0.0
Arterial blood glycerol
Control	69 ± 9	55 ± 11	34 ± 5
GRI-630	67 ± 8	43 ± 4	23 ± 4*
Net hepatic glycerol uptake
Control	1.5 ± 0.1	1.1 ± 0.2	0.6 ± 0.1
GRI-630	1.5 ± 0.2	0.8 ± 0.1	0.4 ± 0.1*
Arterial plasma NEFA
Control	673 ± 95	399 ± 70	166 ± 43
GRI-630	748 ± 89	332 ± 41	105 ± 17
Net hepatic NEFA uptake
Control	2.0 ± 0.2	1.2 ± 0.2	0.5 ± 0.1
GRI-630	1.7 ± 0.2	0.9 ± 0.2	0.2 ± 0.1

Data are mean ± SEM of the basal period and of three hourly time points during each of P1 and P2.

*P < 0.05 vs. control study.