Figure 4.

Control of energy balance by leptin in Atf3^LepRbKO mice. We examined parameters of energy balance in control and Atf3^LepRbKO male (A–D, I) and female (E–H) mice. Longitudinal measurements of body weight (A and E) and food intake (B and F) are shown, along with measurements of adipose mass (C and G) and leptin (F and H). I: Male control and Atf3^LepRbKO mice were fasted for 24 h and then treated with vehicle (PBS) or leptin (5 mg/kg i.p.) before the return of food at the onset of the dark cycle. Food intake over the subsequent 24 h is shown. *P < 0.05 by unpaired t test.