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. 2018 May 8;114(9):2095–2106. doi: 10.1016/j.bpj.2018.03.029

Figure 1.

Figure 1

(A) Topology of the CaV1.2 channel structure with the four transmembrane spanning domains I-IV. Relevant alternative splicing sites are highlighted in black. (B) A schematic representation of the splicing profile of CaV1.2 isoforms 1/8, 1a/8, 1/8a, and 1a/8a is shown. (C) The amino acid alignment of the long-form exon 1a and the short-form exon 1 of CaV1.2 is given.