Figure 3.

Inactivation kinetics of Ca_V1.2 isoforms. (A) A comparison of superimposed traces normalized to the maximal current for 1/8a_1a/8a (left) and 1/8_1a/8 (right) is shown. (B) The voltage-dependent inactivation (Tau inactivation values) was determined with a monoexponential fit at TP of 0, 10, 20, and 30 mV. (C) The percentage of channel inactivation was determined at time points 0.3, 0.6, and 0.9 s. The statistical significance was determined by a Student’s t-test (B), ^∗p < 0.01, ^∗∗p < 0.001, and ^∗∗∗∗p < 0.0001, and (C), statistical significance among groups for each TP was obtained by a two-way ANOVA, followed by a Tukey’s multiple comparisons test, ^∗∗∗p < 0.001, ^∗∗p < 0.01, and n = 8–18 cells.