Table 5.
Average Transfer Energies of α-Synuclein and Its Mutants to 30% Anionic Lipid Vesicles of Different Curvature
| Radius, nm | WT Full-Length on Vesicles | Mutated, 12SER on Vesicles | Truncated, 95 Residues on Vesicles | Truncated, 95 Residues on Tube |
|---|---|---|---|---|
| 40 | −26.3 (0.4) | −28.9 (2.4) | −27.9 (0.7) | −26.6 (0.9) |
| 90 | −24.3 (0.2) | −27.9 (1.2) | −26.5 (0.5) | −26.4 (0.5) |
| 120 | −23.5 (0.3) | −27.7 (2.3) | −26.3 (0.3) | −26.5 (0.1) |
| α | 4.27 ± 0.11 | 1.89 ± 0.19 | 2.54 ± 0.36 | 0.20 ± 0.21 |
The numbers in parentheses indicate SD. The curvature sensitivity parameter is given in the last row. The transfer energies are given in kcal/mol.