Table 2.
Formulation | Polymer ratios | Quercetin (%) | Drug loading (%) | Encapsulation efficiency (%) | Particle size (nm) after centrifugation (10,000 rpm, 10 min) and filtration | PDI | Appearance after storage (−80°C, 2 weeks) | Appearance after lyophilization |
---|---|---|---|---|---|---|---|---|
A1 | P407:TPGS (5:5) | 15 | 3.07 | 20.45 | 19.74±0.65 | 0.189±0.008 | Cloudy | Puffy solid mass |
A2 | L92:TPGS (5:5) | 15 | 5.52 | 36.83 | 119.56±2.04 | 0.184±0.014 | Cloudy | Sticky mass |
A3 | P407:TPGS (7:3) | 20 | 2.95 | 14.74 | 108.51±29.54 | 0.226±0.049 | Cloudy | Puffy solid mass |
A4 | L92:TPGS (7:3) | 10 | 7.57 | 75.75 | 178.42±1.78 | 0.183±0.011 | Cloudy | Sticky mass |
A5 | P123:TPGS (7:3) | 15 | 10.20 | 68.01 | 88.56±1.11 | 0.209±0.011 | Cloudy | Sticky mass |
A6 | L92:TPGS (10:0) | 15 | 12.95 | 86.39 | 403.20±140.98 | 0.267±0.060 | Cloudy | Sticky mass |
A7 | P123:TPGS (10:0) | 10 | 9.47 | 94.77 | 82.40±0.98 | 0.235±0.011 | Cloudy | Sticky mass |
A8 | P407:TPGS (7:3) | 10 | 3.5 | 35.05 | 38.45±10.6 | 0.326±0.030 | Cloudy | Puffy solid mass |
A9 | P123:TPGS (10:0) | 20 | 11.21 | 56.56 | 113.62±0.78 | 0.192±0.002 | Cloudy | Sticky mass |
A10 | P123:TPGS (7:3) | 15 | 10.09 | 67.32 | 104.76±1.63 | 0.277±0.006 | Cloudy | Sticky mass |
A11 | L92:TPGS (7:3) | 20 | 10.14 | 50.72 | 168.43±22.74 | 0.191±0.013 | Cloudy | Sticky mass |
A12 | P407:TPGS (10:0) | 15 | 2.99 | 19.94 | 101.5±16.36 | 0.339±0.032 | Cloudy | Puffy solid mass |
A13 | P123:TPGS (5:5) | 20 | 8.86 | 44.33 | 25.07±2.56 | 0.213±0.016 | Cloudy | Sticky mass |
A14 | P123:TPGS (5:5) | 10 | 7.90 | 79.04 | 18.66±0.12 | 0.157±0.010 | Cloudy | Sticky mass |
A15 | P123:TPGS (7:3) | 15 | 12.88 | 86.07 | 95.59±1.19 | 0.235±0.003 | Cloudy | Sticky mass |
Abbreviations: QCT, quercetin; PDI, polydispersity index; TPGS, tocopheryl polyethylene glycol succinate.