Table 3.
Physicochemical characteristics of different QCT-loaded mixed polymeric micelles with combinations of P123/P407 and L92/P407 with or without TPGS
| Formulation | Polymer ratios | Quercetin (%) | Drug loading (%) | Encapsulation efficiency (%) | Particle size (nm) after centrifugation (10,000 rpm, 10 min) and filtration | PDI | Particle size after lyophilization | PDI after lyophilization |
|---|---|---|---|---|---|---|---|---|
| A16 | P123:P407 (7:3) | 10 | 8.75±0.41 | 87.48±4.15 | 24.83±0.44 | 0.106±0.044 | 37.10±4.23 | 0.136±0.036 |
| A17 | P123:P407 (5:5) | 10 | 3.83±0.52 | 38.28±5.26 | 25.96±0.12 | 0.178±0.040 | 188.36±79.45 | 0.852±0.070 |
| A18 | P123:P407 (3:7) | 10 | 5.02±0.61 | 50.25±6.14 | 26.18±0.18 | 0.112±0.010 | 37.28±5.12 | 0.324±0.025 |
| A19 | L92:P407 (7:3) | 10 | 7.85±0.62 | 78.53±6.27 | 816.63±142.38 | 0.226±0.041 | 99.15±2.57 | 0.274±0.006 |
| A20 | L92:P407 (5:5) | 10 | 8.03±0.41 | 80.28±4.13 | 511.50±297.69 | 0.199±0.057 | 2,356.37±555.01 | 0.633±0.025 |
| A21 | L92:P407 (3:7) | 10 | 4.19±0.71 | 41.94±7.16 | 2,858.57±1,192.54 | 0.391±0.016 | 3,453.28±691.10 | 0.500±0.075 |
| A22 | P123:P407:TPGS (7:2:1) | 10 | 9.01±0.11 | 90.07±1.09 | 26.37±2.19 | 0.204±0.036 | 45.88±13.80 | 0.277±0.004 |
| A23 | L92:P407:TPGS (7:2:1) | 10 | 8.50±0.23 | 84.98±2.34 | 121.94±12.87 | 0.199±0.020 | 266.40±262.08 | 0.279±0.056 |
| A24 | L92:P407:TPGS (5:3:2) | 10 | 8.55±0.27 | 85.54±2.74 | 297.13±147.29 | 0.209±0.063 | 902.13±459.95 | 0.253±0.114 |
Abbreviations: QCT, quercetin; PDI, polydispersity index; TPGS, tocopheryl polyethylene glycol succinate.