Table 3.

Exercise prescription for cycle 0 (weeks 1–4), a fully supervised introduction to exercise while incrementally building exercise capacity

Period	Resistance exercise	Aerobic exercise
Cycle 0 (week 1)
Session 1	1 set × 8RM × 6 exercises	3×30 s at RPE (5), with 90 s recovery
Session 2		10 min at RPE (4) (with 2 min recovery as needed)
Session 3	1 set × 12RM × 6 exercises	3 × 30 s at RPE (5), with 90 s recovery
Cycle 0 (week 2)
Session 1	2 sets × 8RM × 6 exercises	4 × 30 s at RPE (6), with 90 s recovery
Session 2		10 min at RPE (4) (with 2 min recovery as needed)
Session 3	2 sets × 120RM × 6 exercises	4 × 30 s at RPE (6), with 90 s recovery
Cycle 0 (week 3)
Session 1	3 sets × 8RM × 6 exercises	3 × 60 s at RPE (6), with 120 s recovery
Session 2		15 min at RPE (5) (with 2 min recovery as needed)
Session 3	3 sets × 12RM × 6 exercises	3 × 60 s at RPE (6), with 120 s recovery
Cycle 0 (week 4–de-load)
Session 1	2 sets × 8RM × 6 exercises	3 × 30 s at RPE (6), with 90 s recovery
Session 2		10 min at RPE (4) (with 2 min recovery as needed)
Session 3	2 sets × 12RM × 6 exercises	3 × 30 s at RPE (6), with 90 s recovery
Additional descriptions
INTERVAL-GAP4 prescription provides a gradually incremental introduction to the exercise programme across cycle 0 (weeks 1–4). This familiarises and prepares patients for their subsequent participation in moderate-to-high load resistance exercise, as well as high-intensity interval and moderate-intensity continuous aerobic exercise. This cycle also contains a de-load week to increase recovery and promote adaptation prior to progressing into the full prescription. Programme intensity is provided through a repetition maximum (RM) and rating of perceived exertion (RPE) system to support exercise autoregulation and patient management throughout cancer treatment and disease progression as needed.11