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. 2018 May 17;11:2911–2923. doi: 10.2147/OTT.S166597

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© 2018 Liu et al. This work is published and licensed by Dove Medical Press Limited

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Silencing of IGF-1R aggravates inhibitory effects of miR-598.

Notes: (A) MKN-28 and BGC-823 cells were transfected with miR-598 mimic or negative control miRNAs (miR-NC), and then co-transfected with IGF-1R siRNAs or control siRNAs. Western blot analysis was conducted to measure the protein expression of IGF-1R. (B) Cell proliferation was determined in MKN-28 and BGC-823 cells by MTT assay. (C, D). Transwell assays were performed to measure the migration and invasion using crystal violet staining, and then cell invasion was determined. ^*P<0.05 vs miR-NC or si-control.

Abbreviation: mi, mimic.