Table 2.
Mutational burden in sarcomas.
| Sarcoma | Translocation/Mutation | Median mutations/Mb |
|---|---|---|
| soft tissue angiosarcoma | unknown | 3.3 |
| uterus sarcoma (nos) | JAZF1/JJAZ; YWHAE/FAM22 | 2.6 |
| soft tissue rhabdomyosarcoma (nos) | TP53 | 2.5 |
| soft tissue leiomyosarcoma | TP53; ATRX | 2.5 |
| soft tissue sarcoma undifferentiated | KRAS; PIK3CA; SMARCB1 | 2.5 |
| bone osteosarcoma | TP53; RB1 | 2.5 |
| soft tissue sarcoma (nos) | TP53 | 2.5 |
| soft tissue rhabdomyosarcoma embryonal | BRAF; CTNNB1; FGFR4; KRAS | 2.5 |
| soft tissue malignant peripheral nerve sheath tumor (mpnst) | NF1 | 2.5 |
| unknown primary gist | KIT; PDGFRα | 2.5 |
| uterus leiomyosarcoma | TP53; ATRX; MED12 | 2.5 |
| soft tissue myxofibrosarcoma | NF1; TP53 | 2.2 |
| small intestine gist | KIT | 1.8 |
| stomach gist | PDGFRα; KIT | 1.8 |
| soft tissue chondrosarcoma | COL2A1; TP53; IDH1 | 1.7 |
| soft tissue solitary fibrous tumor | NAB2/STAT6 | 1.7 |
| soft tissue fibrosarcoma | ETV6/NTRK3 | 1.7 |
| uterus endometrial stromal sarcoma | JAZF1/SUZ12; YWHAE/FAM22; ZCH7/BCOR; PFH1/JAZF1; PFH1/EPC1; PFH1/MEAF6 | 1.7 |
| bone chondrosarcoma | TFG/NR4A3; TCF12/NR4A3; AF15/NR4A3; EWSR1/NR4A3 | 1.7 |
| soft tissue Ewing sarcoma | EWSR1/FLI1; EWSR1/ERG; EWSR1/E1AF; EWSR1/ETV1; EWSR1/FEV | 1.7 |
| soft tissue liposarcoma | FUS/DDIT3; EWSR1/DDIT3 | 1.7 |
| soft tissue desmoplastic small round cell tumor | EWSR1/WT1 | 1.7 |
| soft tissue synovial sarcoma | SS18/SSX1; SS18/SSX2; SS18/SSX4 | 1.7 |
| soft tissue rhabdomyosarcoma alveolar | PAX7/FOXO1; PAX3:FOXO1 | 1.7 |
| bone chordoma | T (Brachyury) | 1.3 |
| soft tissue fibromatosis | CTNNB1; APC | 0.9 |
| malignant rhabdoid tumor | SMARCB1 | 0.2 |
NOS = not otherwise specified.