Table 2.
The most commonly adopted eligibility criteria variables and their prevalence in AD trials (the last column with column header as “#” indicates the number of parent concepts)
| SNOMED-CT Concept Representation for Commonly Adopted Eligibility Variables | SNOMED_ID | Prevalence | Type of | level | Parent_SNOMED ID | # |
|---|---|---|---|---|---|---|
| Clinical finding | 404684003 | 97.09% | finding | 1 | 138875005 | 1 |
| Disease | 64572001 | 94.25% | disorder | 2 | 404684003 | 1 |
| Mental disorder | 74732009 | 82.21% | disorder | 3 | 64572001 | 1 |
| Disorder of brain | 81308009 | 79.50% | disorder | 3 | 64572001 | 1 |
| Organic mental disorder | 111479008 | 74.74% | disorder | 4 | 74732009, 81308009 | 2 |
| Dementia | 52448006 | 74.60% | disorder | 5 | 111479008 | 1 |
| Cerebral degeneration presenting primarily with dementia | 279982005 | 64.62% | disorder | 3 | 64572001 | 1 |
| Clinical history and observation findings | 250171008 | 64.55% | finding | 2 | 404684003 | 1 |
| Alzheimer’s disease | 26929004 | 64.29% | disorder | 6 | 52448006, 279982005 | 2 |
| Staging and scales | 254291000 | 60.65% | staging scale | 1 | 138875005 | 1 |
| Assessment scales | 273249006 | 60.65% | assessment scale | 2 | 254291000 | 1 |
| Procedure | 71388002 | 58.33% | procedure | 1 | 138875005 | 1 |
| Observable entity | 363787002 | 51.19% | observable entity | 1 | 138875005 | 1 |
| Mini-mental state examination | 273617000 | 46.63% | assessment scale | 3 | 273249006 | 1 |
| Qualifier value | 362981000 | 45.24% | qualifier value | 1 | 138875005 | 1 |
| General finding of observation of patient | 118222006 | 41.14% | finding | 3 | 250171008 | 1 |
| Presenile dementia | 12348006 | 39.62% | disorder | 6 | 52448006 | 1 |
| Disorder of cardiovascular system | 49601007 | 39.55% | disorder | 3 | 64572001 | 1 |
| Psychological finding | 116367006 | 38.96% | finding | 3 | 250171008 | 1 |
| Mental state, behavior and/or psychosocial function finding | 384821006 | 38.96% | finding | 4 | 116367006 | 1 |
| Disorder of nervous system | 118940003 | 35.78% | disorder | 3 | 64572001 | 1 |
| Current chronological age | 424144002 | 34.06% | observable entity | 3 | 105727008 | 1 |
| Age AND/OR growth period | 105727008 | 34.06% | observable entity | 2 | 363787002 | 1 |
| Disorder of blood vessel | 27550009 | 33.33% | disorder | 4 | 49601007 | 1 |
| Evaluation procedure | 386053000 | 33.33% | procedure | 2 | 71388002 | 1 |
| Disorder of body system | 362965005 | 32.41% | disorder | 3 | 64572001 | 1 |
| Cerebrovascular disease | 62914000 | 32.28% | disorder | 5 | 27550009 | 1 |
| Magnetic resonance imaging | 113091000 | 31.88% | procedure | 2 | 71388002 | 1 |
| Disorder by body site | 123946008 | 30.16% | disorder | 3 | 64572001 | 1 |
| Procedure by method | 128927009 | 25.79% | procedure | 2 | 71388002 | 1 |
| Mood disorder | 46206005 | 25.73% | disorder | 4 | 74732009 | 1 |
| Substance abuse | 66214007 | 25.66% | disorder | 3 | 64572001 | 1 |
| Descriptor | 272099008 | 24.80% | qualifier value | 2 | 362981000 | 1 |
| Cerebrovascular accident | 230690007 | 24.54% | disorder | 6 | 62914000 | 1 |
| Global assessment of functioning -1993 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition adaptation | 284061009 | 23.94% | assessment scale | 3 | 273249006 | 1 |
| Systemic disease | 56019007 | 23.35% | finding | 4 | 118222006 | 1 |
| General body state finding | 82832008 | 22.49% | finding | 4 | 118222006 | 1 |
| Impaired cognition | 386806002 | 21.43% | finding | 5 | 384821006 | 1 |
| System disorder of the nervous system | 230226000 | 21.16% | disorder | 4 | 118940003 | 1 |
| Movement disorder | 60342002 | 21.16% | disorder | 5 | 230226000 | 1 |
| Extrapyramidal disease | 76349003 | 21.16% | disorder | 6 | 60342002 | 1 |
| Disorder of head | 118934005 | 21.03% | disorder | 4 | 123946008 | 1 |
| Depressive disorder | 35489007 | 21.03% | disorder | 5 | 46206005 | 1 |