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. 2018 May 1;24(5):486–504. doi: 10.1089/acm.2017.0053

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© Manoj K. Bhasin et al., 2018; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 3. — Transcriptome changes and significantly affected pathways in hypertension patients after 8 weeks of RR intervention. (A) A heatmap of significantly differentially expressed genes after 8 weeks of RR training. Relative gene expression differences pre- to post-RR intervention for significantly differentially expressed genes are shown with a pseudocolor scale (-1 to 1), with red denoting higher gene expression and green denoting lower expression after intervention. (B) Pathway enrichment analysis of significantly upregulated genes, and (C) pathway enrichment analysis of significantly downregulated genes. Selected top pathways of differentially upregulated (B) and downregulated (C) genes are shown. The y-axis represents pathways and the x-axis the - log transformed p-value (e.g., a value of 2 represents a p-value of 0.01). ER, endoplasmic reticulum; IL, interleukin; RR, relaxation response.

FIG. 3. — Transcriptome changes and significantly affected pathways in hypertension patients after 8 weeks of RR intervention. (A) A heatmap of significantly differentially expressed genes after 8 weeks of RR training. Relative gene expression differences pre- to post-RR intervention for significantly differentially expressed genes are shown with a pseudocolor scale (-1 to 1), with red denoting higher gene expression and green denoting lower expression after intervention. (B) Pathway enrichment analysis of significantly upregulated genes, and (C) pathway enrichment analysis of significantly downregulated genes. Selected top pathways of differentially upregulated (B) and downregulated (C) genes are shown. The y-axis represents pathways and the x-axis the - log transformed p-value (e.g., a value of 2 represents a p-value of 0.01). ER, endoplasmic reticulum; IL, interleukin; RR, relaxation response.