Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 1;24(5):486–504. doi: 10.1089/acm.2017.0053

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Manoj K. Bhasin et al., 2018; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

FIG. 5. — Identification of gene expression changes and pathways significantly correlating with BP changes after 8 weeks of RR intervention. (A) Correlation analysis for differentially expressed transcripts in BP responders and nonresponders for which changes in the pre-MAP to post-MAP (equivalent to DBP +1/3[SBP-DBP]) and changes in gene expression were significantly correlated (p < 0.05). Out of these 121 genes, 46 and 75 genes showed significant positive (right graph) and negative (left graph) correlation, respectively, between gene expression change (x-axis) and MAP change (y-axis). (B) Pathway analysis of genes depicting significant correlation with BP changes. The y-axis represents pathways and the x-axis the -log transformed p-value (e.g., a value of 2 represents a p-value of 0.01). (C) Interactive network of BP change correlated genes that is enriched with metabolism (lipid, nucleic acid, and drug metabolism) and connective tissue disorder-related genes. (D) Interactive network of BP change correlated genes that is enriched with cardiovascular disease-related genes. For both (C, D), network nodes are colored on the basis of correlation between gene expression and BP (i.e., positively correlated = red, negatively correlated = green, colorless nodes = no correlation). BP, blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; RR, relaxation response; SBP, systolic blood pressure.