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. 2018 May 1;24(5):486–504. doi: 10.1089/acm.2017.0053

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© Manoj K. Bhasin et al., 2018; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 7. — Upstream regulator analysis of genes significantly linked to BP response in HTN patients. Upstream regulator analysis of genes significantly linked to BP response in HTN patients. This analysis helps to identify upstream regulators that are predicted to be significantly activated or inhibited upstream of the gene expression alterations after the RR training. Top upstream regulators identified from analysis of downregulated (A) and upregulated (B) genes from the RR HTN Responder Signature. The upstream regulators that are predicted to be activated and inhibited are orange and blue, respectively. The downstream targets of each regulators are shown with red (genes upregulated by RR) and green (genes downregulated by RR). BP, blood pressure; HTN, hypertension; RR, relaxation response.