TABLE III. Analysis of single nucleotide polymorphisms located in IL10 and IFNG genes.
| Stage A N= 110 |
Stage B1 N= 163 |
Stage C N= 133 |
A versus B1 | A versus C | B1 versus C | A versus B1+C | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ORa [95% CI] | p-value | ORa [95% CI] | p-value | ORa [95% CI] | p-value | ORa [95% CI] | p-value | ||||
| IL10-3575T > A rs1800890 | |||||||||||
| AA | 45 (0.59) | 78 (0.57) | 65 (0.58) | Reference | |||||||
| AT | 23 (0.31) | 54 (0.39) | 39 (0.35) | 1.4 [0.8-2.7] | 0.14 | 1.2 [0.6-2.2] | 0.64 | 0.8 [0.5-1.4] | 0.47 | 1.3 [0.7-2.3] | 0.27 |
| TT | 8 (0.10) | 5 (0.04) | 8 (0.07) | 0.4 [0.1-1.5] | 0.7 [0.2-2.0] | 1.6 [0.5-5.4] | 0.5 [0.2-1.5] | ||||
| T carriers | 31 (0.41) | 59 (0.43) | 47 (0.42) | 1.2 [0.6-2.2] | 0.57 | 1.0 [0.6-1.9] | 0.86 | 0.9 [0.5-1.5] | 0.66 | 1.1 [0.6-1.9] | 0.66 |
| IL10-1082G > A rs1800896 | |||||||||||
| GG | 51 (0.55) | 61 (0.44) | 56 (0.50) | Reference | |||||||
| GA | 31 (0.34) | 68 (0.50) | 47 (0.41) | 1.9 [1.1-3.3] | 0.07 | 1.4 [0.8-2.5] | 0.50 | 0.7 [0.4-1.3] | 0.48 | 1.6 [0.9-2.7] | 0.15 |
| AA | 10 (0.11) | 9 (0.06) | 10 (0.09) | 0.9 [0.3-2.4] | 0.9 [0.4-2.4] | 1.1 [0.4-3.0] | 0.9 [0.4-2.1] | ||||
| A carriers | 41 (0.45) | 77 (0.56) | 57 (0.50) | 1.6 [1.0-2.8] | 0.07 | 1.3 [0.7-2.2] | 0.40 | 0.8 [0.5-1.3] | 0.35 | 1.4 [0.9-2.3] | 0.14 |
| IL10-819C > T rs1800871 | |||||||||||
| CC | 25 (0.44) | 57 (0.43) | 38 (0.38) | Reference | |||||||
| CT | 26 (0.46) | 60 (0.45) | 48 (0.48) | 1.0 [0.5-1.9] | 0.97 | 1.2 [0.6-2.5] | 0.63 | 1.2 [0.7-2.2] | 0.74 | 1.1 [0.6-2.0] | 0.78 |
| TT | 6 (0.10) | 16 (0.12) | 14 (0.14) | 1.1 [0.4-3.2] | 1.6 [0.6-4.9] | 1.1 [0.5-2.7] | 1.4 [0.5-3.8] | ||||
| T carriers | 32 (0.56) | 76 (0.57) | 62 (0.62) | 1.0 [0.5-1.9] | 0.95 | 1.3 [0.7-2.6] | 0.41 | 1.2 [0.7-2.1] | 0.46 | 1.1 [0.6-2.1] | 0.64 |
| IFNG+874T > A rs2430561 | |||||||||||
| TT | 27(0.36) | 72 (0.52) | 53 (0.47) | Reference | |||||||
| AT | 28 (0.38) | 53 (0.38) | 44 (0.39) | 0.7 [0.4-1.4] | 0.03 | 0.8 [0.4-1.6] | 0.10 | 1.2 [0.7-2.0] | 0.77 | 0.8 [0.4-1.4] | 0.02 |
| AA | 19 (0.26) | 14 (0.10) | 15 (0.13) | 0.3 [0.1-0.7] | 0.4 [0.2-0.9] | 1.3 [0.6-3.0] | 0.3 [0.2-0.7] | ||||
| A carriers | 47 (0.64) | 67 (0.48) | 59 (0.52) | 0.6 [0.3-1.0] | 0.06 | 0.6 [0.4-1.2] | 0.17 | 1.2 [0.7-2.0] | 0.50 | 0.6 [0.3-1.0] | 0.06 |
a
odds ratio (OR) values shown are corrected for gender and ethnicity; results are shown as n (frequency); CI: confidence interval; rotal genotype counts can vary due to different genotypic call rates.