TABLE V. Analysis of single nucleotide polymorphisms located in the TNFR1 and TNFR2 cluster.
| Stage A N= 110 |
Stage B1 N= 163 |
Stage C N= 133 |
A versus B1 | A versus C | B1 versus C | A versus B1+C | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ORa [95% CI] | p-value | ORa [95% CI] | p-value | ORa [95% CI] | p-value | ORa [95% CI] | p-value | |||||
| TNFR1 +36 A > G rs767455 | ||||||||||||
| GG | 47 (0.52) | 66 (0.48) | 46 (0.40) | Reference | ||||||||
| AG | 36 (0.40) | 58 (0.42) | 56 (0.49) | 1.1 [0.6-2.0] | 0.86 | 1.6 [0.9-2.8] | 0.24 | 1.3 [0.8-2.2] | 0.58 | 1.3 [0.8-2.2] | 0.44 | |
| AA | 8 (0.08) | 13 (0.10) | 13(0.11) | 1.2 [0.5-3.3] | 1.8 [0.7-4.7] | 1.3 [0.5-3.2] | 1.5 [0.6-3.5] | |||||
| A carriers | 44 (0.48) | 71 (0.52) | 69 (0.60) | 1.2 [0.7-2.0] | 0.60 | 1.6 [0.9-2.8] | 0.09 | 1.3 [0.8-2.2] | 0.30 | 1.4 [0.8-2.2] | 0.21 | |
| TNFR2+1466 A > G rs1061624 | ||||||||||||
| AA | 25 (0.27) | 32 (0.23) | 36 (0.32) | Reference | ||||||||
| AG | 49 (0.53) | 72 (0.53) | 53 (0.46) | 1.1 [0.6-2.2] | 0.80 | 0.8 [0.4-1.5] | 0.63 | 0.7 [0.4-1.2] | 0.43 | 0.9 [0.5-1.6] | 0.78 | |
| GG | 18 (0.20) | 33 (0.24) | 25 (0.22) | 1.3 [0.6-3.0] | 1.0 [0.4-2.2] | 0.7 [0.4-1.5] | 1.2 [0.6-2.4] | |||||
| G carriers | 67 (0.73) | 105 (0.77) | 78 (0.68) | 1.2 [0.6-2.2] | 0.59 | 0.8 [0.4-1.5] | 0.54 | 0.7 [0.4-1.2] | 0.20 | 1.0 [0.6-1.7] | 0.99 | |
a
odds ratio (OR) values shown are corrected for gender and ethnicity; results are shown as n (frequency); CI: confidence interval; total genotype counts can vary due to different genotypic call rates.