TABLE VI. Summary of meta-analysis of published studies for TNF −308 G > A (rs1800629) and chagasic cardiomyopathya .
| Meta-analysis of published studies | Meta-analysis of published studies and present data | |||||||
|---|---|---|---|---|---|---|---|---|
| TNF −308 G > A rs1800629 | CCC N = 424 |
ASY N = 339 |
ORb [95% CI] | p-value | CCC N = 534 |
ASY N = 472 |
ORb [95% CI] | p-value |
| Allele A | 124 | 60 | 1.7 [1.1 - 2.6] | 0.02 | 147 | 83 | 1.4 [0.9 - 2.3] | 0.14 |
| A carriers | 117 | 56 | 2.1 [1.1 - 3.1] | 0.02 | 139 | 78 | 1.5 [0.9 - 2.6] | 0.15 |
| AA Genotype | 7 | 4 | 1.3 [0.4 - 4.5] | 0.70 | 8 | 5 | 1.2 [0.4 - 3.7] | 0.77 |
a
results are shown for random-effects model;
b
odds ratio (OR);
CCC: chronic chagasic cardiomyopathy; ASY: asymptomatic group; CI: confidence interval; the study by Rodríguez-Pérez et al. (2005) was excluded due to deviations from HWE in the control group.