Table I.
Characteristics of lesions treated with very low-dose radiation therapy and standard dose radiation therapy and side effects of treatment
| Lesion information | VLD-RT (n = 51) | SD-RT (n = 37) | P value* | ||
|---|---|---|---|---|---|
| Lesion diagnosis, n (%) | .1912 | ||||
| pcMZL | 34 (66.7) | 17 (48.6) | |||
| pcFCL | 17 (33.3) | 18 (51.4) | |||
| NOS | 0 | 2 (0.05) | |||
| Location, n (%) | .5184 | ||||
| Head | 15 (29.4) | 17 (46.0) | |||
| Trunk | 21 (41.2) | 8 (21.6) | |||
| Extremities | 15 (29.4) | 12 (32.4) | |||
| Lesion size (cm) | .0145 | ||||
| N | 33 | 27 | |||
| Range | 0.2–6.0 | 0.2–14.0 | |||
| Median | 1.0 | 3.0 | |||
| Duration of follow-up ( years) | .0271 | ||||
| Range | 0.02–12.6 | 0.2–18.8 | |||
| Median | 3.9 | 7.0 | |||
| Immediate side effects, n (%) | <.0001 | ||||
| No | 43 (84.3) | 8 (21.6) | |||
| Yes | |||||
| Erythema | 8 (15.7) | 5 | 29 (78.4) | 22 | |
| Itch | 1 | 2 | |||
| Fatigue | 1 | 2 | |||
| PIH | 1 | 0 | |||
| Erythema and fatigue | 0 | 1 | |||
| Itch and fatigue | 0 | 1 | |||
| Pain and fatigue | 0 | 1 | |||
| Long-term side effects (>6 months), n (%) | .0036 | ||||
| None | 47 (92.2) | 22 (59.5) | |||
| Yes | |||||
| PIH | 4 (7.8) | 2 | 15 (40.5) | 9 | |
| Hair loss | 2 | 4 | |||
| Pain | 0 | 1 | |||
| PIH and hair loss | 0 | 1 | |||
| CR, n (%) | .4937 | ||||
| No | |||||
| No response | 3 (5.9) | 0 | 1 (2.7) | 1 | |
| PR | 2 | 0 | |||
| PR with recurrence | 1 | 0 | |||
| Yes | |||||
| CR | 48 (94.1) | 39 | 36 (97.3) | 25 | |
| CR with in-field occurrence of new lesions | 5 | 2 | |||
| CR with out-of-field occurrence of new lesions | 0 | 8 | |||
| CR with relapse of same lesions | 4 | 1 | |||
CR, Complete response; NOS, not otherwise specified; pcFCL, primary cutaneous follicle center lymphoma; pcMZL, primary cutaneous marginal zone lymphoma; PIH, postinflammatory hyperpigmentation; PR, partial response; SD-RT, standard dose radiation therapy; VLD-RT, very low-dose radiation therapy.
*
Obtained from generalized repeated measures linear models with the appropriate link function based on the distribution of the lesion characteristic. Continuous measures were transformed when their distributions were skewed.