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. Author manuscript; available in PMC: 2018 May 21.
Published in final edited form as: Physiol Behav. 2017 Jan 12;178:103–109. doi: 10.1016/j.physbeh.2017.01.021

Table 2.

Impact of Visible Burrow System and Chronic Variable Stress on Hippocampal Gene Expression, Receptor Binding and Morphology

Dom Sub NRS CVS
Gene Expression
  Glucocorticoid Receptor - ↓1(CA1) ↓(CA1) ↓(CA1,DG),-1
  Mineralocorticoid Receptor - ↓1(CA1) ↓(CA1) ↓(CA1,CA3,DG),-1
  GAP43 - ↓(CA1) n.d. n.d.
  Proenkephalin - - n.d. n.d.
  GAD65 - - n.d. -
  GAD67 - ↑(CA1,CA3,DG) n.d. ↑(CA3,DG)
  BDNF - - - -
Receptor Autoradiography
  5HT1A ↓(CA1, CA3) ↓(CA1,CA3,DG) - n.d.
  5HTT ↓(CA3) ↓(CA3) n.d. n.d.
Receptor Binding
  Glucocorticoid Receptor - - - n.d.
  Mineralocorticoid Receptor - - - n.d.
Morphology (CA3)
  Pyramidal Cell Branching: basal - - - n.d.
  Pyramidal Cell Branching: apical ↓ ↓ - n.d.
  Dendritic Length: basal - - - n.d.
  Dendritic Length: apical ↓ - - n.d.

Data compiled from refs [2, 11, 12, 15, 19, 25, 26, 55]

↑ = increased expression relative to controls; ↓ = decreased expression relative to controls; -= no change from control; n.d. = not determined

1

= small decrease (~20%) observed in [11], but not replicated in [12].