Table 1.
Phyllanthusmin analogues and corresponding antiproliferative data in HT-29 and OVCAR3 cell lines expressed as IC50 values in µM.
| Cmpd | Carbohydrate | HT-29 | OVCAR3 |
|---|---|---|---|
| 6a | l-arabinose (−OAc) | 0.14 | 0.29 |
| 6b | l-arabinose (−OH) | 3.2 | 4.8 |
| 6c | l-arabinose (−OMe) | 0.13 | 0.81 |
| 7a | d-xylose (−OAc) | 0.16 | 0.57 |
| 7b | d-xylose (−OH) | 1.4 | 0.69 |
| 7c | d-xylose (−OMe) | 0.018 | 7.6 |
| 8a | d-glucose (−OAc) | 0.043 | >10 |
| 8b | d-glucose (−OH) | 4.8 | >10 |
| 9a | d-galactose (−OAc) | 0.044 | 0.36 |
| 9b | d-galactose (−OH) | >10 | >10 |
| 10 | d-arabinose (−OAc) | 0.046 | 0.37 |
| 11 | Lactose (−OAc) | 2.0 | >10 |
| 12 | d-xylose (−OMe) | 1.7 | 0.45 |
| 13 | l-arabinose (−OAc) | >10 | >10 |
| 17 | l-arabinose (−OAc) | 1.4 | >10 |
| 18 | l-arabinose (−OAc) | 0.47 | >10 |
| Taxol | 0.011 | 0.011 | |
| Etoposide | 15 | 2.9 |