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. 2018 May 21;5(3):ENEURO.0038-18.2018. doi: 10.1523/ENEURO.0038-18.2018

Figure 2.

Figure 2.

DNA methylation is required for RNA-induced enhancement of the SWR. A, Experimental protocol for inducing sensitization in the second donor group. B, Mean posttest duration of the SWR (n = 38). The training produced sensitization (mean posttest SWR = 56.4 ± 1.4 s, and mean pretest SWR = 1.1 ± 0.1 s; W = 741, p < 0.001). C, Experimental protocol for testing the effect of DNMT inhibition on RNA-induced enhancement of the SWR. RG-108/vehicle was injected into animals 5–10 min after the RNA injection. D, Mean postinjection duration of the SWR in the RNA-Veh (n = 3) and RNA-RG (n = 7) groups. The mean duration of the SWR in the RNA-Veh group (35.7 ± 7.7 s) was significantly longer than that in the RNA-RG group (1.4 ± 0.3 s; U = 27, p < 0.02). Moreover, the posttest SWR was sensitized compared to the pretest reflex in the RNA-Veh group (paired t test, p < 0.05), but not in the RNA-RG group (p > 0.4).